PReS-FINAL-2283: Systemic lupus erythematosus (SLE) in children and adolescents in pediatric unite, institute of rheumatology Belgrade, Serbia

Results Thirty seven patients (36 f, 1 m) of SLE were reviewed.. The mean age at disease onset was 15 years with a range of 7-19 years. The most common features were mucocutaneus (malar rash in 84,8%, photosensitivity in 69,7%); musculoskeletal (arthritis in 87,9%) and hematological (leucopenia in 75,8%, anemia in 69,7%, Coombs test positive in 18,9% and, thrombocytopenia in 28%). Renal involvement occurred in 45,5% of children. CNS manifestations in 51,2%. ANA was positive in 97,3%, Anti dsDNA in 81,1%, Anti Sm in 40% of our patients. Corticosteroid treatment was given in all patients in the form of prednisone (100%) and methylprednisolone, iv pulses were applied in 58,8%. Antimalarics were used in 97.3%, azathiophrine in 48,6%, micophenolat-mofetil in 21,6% and cyclosporine in 3,8% of children. The most common complications were hypertension, hypercorticism and opportunistic infections. Three patients died during the period of the study, two girls according to antiphospholipid syndrome complications, one of infection (sepsis).